N-sulfoglucosamine sulfohydrolase
| N-sulfoglucosamine sulfohydrolase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 3.10.1.1 | ||||||
| CAS number | 37289-41-1 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a N-sulfoglucosamine sulfohydrolase (EC 3.10.1.1) is an enzyme that catalyzes the chemical reaction
- N-sulfo-D-glucosamine + H2O
D-glucosamine + sulfate
Thus, the two substrates of this enzyme are N-sulfo-D-glucosamine and H2O, whereas its two products are D-glucosamine and sulfate.
This enzyme belongs to the family of hydrolases, specifically those acting on sulfur-nitrogen bonds. The systematic name of this enzyme class is N-sulfo-D-glucosamine sulfohydrolase. Other names in common use include sulfoglucosamine sulfamidase, heparin sulfamidase, 2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate, and sulphohydrolase). This enzyme participates in glycosaminoglycan degradation and glycan structures - degradation.
References
- Dietrich CP (1969). "Enzymic degradation of heparin A sulphamidase and a sulphoesterase from Flavobacterium heparinum". Biochem. J. 111 (1): 91–5. PMC 1187498. PMID 5775690. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1187498.
- Mahuran D, Clements P, Hopwood J (1983). "A rapid four column purification of 2-deoxy-D-glucoside-2-sulphamate sulphohydrolase from human liver". Biochim. Biophys. Acta. 757 (3): 359–65. PMID 6849981.